郑晓燕

郑晓燕

位:工学博士

门:制药工程系

职称/职务:副教授/硕士生导师

通信地址: 西安市太白北路229710069,WilliamHill官网

电话/传真: 13379025584(H)

E-mail: zy129@nwu.edu.cn

研究方向:

[1] 纳米功能材料

[2] 生物医用材料

[3] 药物的缓控释放与预防医学

教育经历:

2013/09—2016/12,WilliamHill官网应用化学专业,博士在读

2009/03—2011/12,WilliamHill官网化学工程专业,硕士在读

2001/09—2005/06,WilliamHill官网生物工程专业,本科在读

科研与学术工作经历:

2021/09 - 今,   WilliamHill官网制药工程专业,副教授

2021/06-2021/08,WilliamHill官网制药工程专业,讲师

2017/09-2021/05,威廉希尔中文网站,生命科学学院,团队博士后

2005/07-2009/02,西安迈克森新材料有限公司质检科,质检员

科研项目(课题)情况

1)主持项目

[1] 药用多肽高效分离、纯化关键技术(开展药用多肽相分离去除内毒素技术开发),国家重点研发计划(2021YFC2103902)子课题,2021.12-2025.1270万元,主持人;

[2] 复合离子杂化仿生人工骨支架的3D打印构筑与骨缺损修复规律探究,国家自然科学基金青年基金,219081792020/01-2023/1226万元,主持人;

[3] 基于杂质离子辅助的室温矿化可控合成羟基磷灰石的关键技术研究,陕西省自然科学基金,2018JQ20522018/01-2019/123万元,主持人;

[4] 纳米磷灰石的理化特性对3D打印人工骨性能的影响研究,中国博士后科学基金(第63批),2018M6335562018/03-2019/085万元,主持人;

[5] 多离子掺杂纳米羟基磷灰石的可控合成与表面改构研究,陕西省教育厅项目,17JS1252017/06-2019/123万元,主持人;

[6] 富县采油厂采出污水加药配方优化研究,2018/06-2019/1215.4万元,主持人;

2)参与项目

[1] 国家自然科学基金面上项目,21978236,人参皂苷Rk3靶向PD-L1调节肠道菌群对肝癌的抑制及作用机制研究,2020/01-2023/1266万元,排2

[2] 国家自然科学基金面上项目,21878246,人参皂苷Rh4对胰岛β细胞的修复及降糖机理研究,2019/01-2022/1266万元,排3

[3] 国家自然科学基金面上项目,21776228,人参皂苷Rg5分子尺度调控胰岛素敏感性改善II型糖尿病糖代谢机制,2018/01-2021/1264万元,排2

[4] 国家自然科学基金面上项目,21676215,羟基磷灰石/DNA亚纳米尺度复合材料共组装规律及性质研究,2017/01-2020/1270万元,排3

[5] 陕西省科技厅项目,2017SF-201,用于软骨修复的亚纳米HAp/胶原蛋白高强度水凝胶的制备,2017/01-2019/1212万元,排2

授权发明专利

[1] 郑晓燕,马海霞,范代娣,惠俊峰,一种具有红色荧光标记的铕掺杂羟基磷灰石单晶纳米棒的制备方法,发明专利授权号:ZL 201510348489.6(授权日期:2020.10.16

[2] 郑晓燕,马海霞,范代娣,惠俊峰,一种低温矿化制备亚纳米羟基磷灰石超细针的方法,发明专利授权号:ZL 201510605232.4。(授权日期:2019.10.25

[3] 郑晓燕,马海霞,范代娣,惠俊峰,韩静,一种柔性超细羟基磷灰石亚纳米线的制备方法,发明专利授权号:ZL 201510605584.X。(授权日期:2017.07.28

[4] 郑晓燕,范代娣,惠俊峰,朱晨辉,马晓轩,姜西娟,一种新型医用止血凝胶敷料的制备方法,发明专利授权号:ZL201710503854.5。(授权日期:2020.02.18

[5] 郑晓燕,范代娣,惠俊峰,段志广,李伟娜,姜西娟,一种含沸石止血凝胶敷料的制备方法,发明专利授权号:ZL201710503858.3。(授权日期:2020.04.21

[6] 衡春宁,郑晓燕,张小勇,范代娣,惠俊峰,一种羟基磷灰石单晶纳米棒的亲水性改性方法,ZL 201510606934.4。(授权日期:2018.01.23

[7] 范代娣,米钰,郑晓燕,马沛,惠俊峰,一种新型类人胶原蛋白止血敷料,ZL201610073664.X,(授权日期:2018.10.26)。

[8] 范代娣,马沛,郑晓燕,米钰,惠俊峰,一种抗菌性类人胶原蛋白创面医护膜敷料,专利授权号:ZL 2016100736635,(授权日期:2019.01.25

[9] 惠俊峰,范代娣,米钰,郑晓燕,邓建军,姜西娟,一种分离介质的制备方法,专利授权号:ZL 201710503815.8(授权日期:2019.11.19

[10] 惠俊峰,范代娣,米钰,马沛,郑晓燕,姜西娟,一种超多孔水凝胶的制备方法,专利授权号:ZL 201710503785.8(授权日期:2019.11.19

[11] 范代娣,惠俊峰,朱晨辉,马晓轩,郑晓燕,姜西娟,一种防渗防粘连多孔止血凝胶敷料的制备方法,专利授权号:ZL 201710503847.5。(授权日期:2020.04.28

[12] 惠俊峰,范代娣,米钰,马沛,郑晓燕,姜西娟,一种用于组织填充的惰性多孔水凝胶的制备方法,专利授权号:ZL201710503866.8。(授权日期:2020.04.28

[13] 惠俊峰,贺其雅,范代娣,郑晓燕,陈昱桥,毛淳怡,杨智键,一种多孔骨修复支架材料及其制备方法,专利授权号:ZL201910177807.5。(授权日期:2020.06.02

[14] 范代娣,朱晨辉,惠俊峰米钰,郑晓燕马沛,雷桓;一种可生物降解的组织工程皮肤支架的制备方法,专利授权号:ZL 201710802649.9。(授权日期:2020.10.30

发表论文

[1] Mingming Wang, Jiaxin Yao, Shihong Shen, Chunning Heng, Yanyi Zhang, Tao Yang*, Xiaoyan Zheng*, A scaffold with zinc-whitlockite nanoparticles accelerates bone reconstruction by promoting bone differentiation and angiogenesis. Nano Research, 2023, 16 (1): 757-770.SCI一区, IF:10.269

[2] Chunning Heng, Wan Liu, Xiaoyan Zheng*, Xiaoxuan Ma, Junfeng Hui, Daidi Fan*, Dopamine and DNA functionalized manganese whitlockite nanocrystals for magnetic resonance imaging and chemo-photothermal therapy of tumors. Colloids and Surfaces B: Biointerfaces,2023, 222: 113120.SCI二区, IF: 5.998

[3] Zichen Yang, Tianyu Yao, Xiaoyan Zheng*, Junfeng Hui, Daidi Fan*. Eu3+/Tb3+-doped whitlockite nanocrystals: controllable synthesis, cell imaging, and the degradation process in the bone reconstruction. Nano Research, 2022, 15, 1303–1309.SCI一区, IF:10.269

[4] Jingjing Shao,Xiaoyan Zheng*,Linlin Qu,Hui Zhang,Huifang Yuan,Junfeng Hui,Yu Mi,Pei Ma,Daidi Fan*, Ginsenoside Rg5/Rk1 ameliorated sleep via regulating the GABAergic/serotoninergic signaling pathway in rodent model. Food & Function, 2020, 11, 1245-1257.SCI一区, IF:4.171

[5] Jiaxin Yao,Heng Zhang,Zejun Zhao,Zhixiao Zhu,Jialing Yao,Xiaoyan Zheng*andYong Yang*Melamine-Assisted Synthesis of Porous V2O3/N-doped Carbon Hollow Nanospheres for Efficient Sodium-Ion StorageDalton Transactions, 2021,50:3867-3873.SCI二区, IF:4.108

[6] Huifang Yuan # , Xiaoyan Zheng # , Wan Liu, Hui Zhang, Jingjing Shao, Jiaxin Yao,Chunyi Mao, Junfeng Hui*, Daidi Fan*, A novel bovine serum albumin and sodiumalginate hydrogel scaffold doped with hydroxyapatite nanowires for cartilage defectsrepair, Colloids and Surfaces B: Biointerfaces, 2020, 192 (111041): 1-9.SCI二区, IF:4.389

[7] Xiaoyan Zheng, Dong Feng, Liangrong Yang*, Junfeng Hui,Jiemiao Yu, Qiyu Meng,Huizhou Liu*, Daidi Fan*, Mild stir-assisted membrane dispersion for enhancing propionic acid extraction, Chinese Journal of Chemical Engineering. 2019, 27(11): 2666-2674.(SCI二区, IF:3.898)

[8] Xiaoyan Zheng, Junfeng Hui, Hui Li, Chenhuizhu, Xiufu Hua, Haixia Ma, Daidi Fan, Fabrication of novel biodegradable porous bone scaffolds based on amphiphilic hydroxyapatite nanorods,Materials Science and Engineering C, 2017, 75: 699-705. SCI二区, IF: 5.880

[9] Xiaoyan Zheng, Meiying Liu, Junfeng Hui, Daidi Fan*, Haixia Ma, Xiaoyong Zhang*, Yaoyu Wang and Yen Wei*,Ln3+-doped hydroxyapatite nanocrystals:controllable synthesis and cell imaging, Physical Chemistry Chemical Physics,2015, 17: 20301-20307.(SCI二区, IF=3.430)

[10]Jianpeng Sun#, Xiaoyan Zheng#, Hui Li,Daidi Fan,Zhanping Song, Haixia Ma,Xiufu Hua*, Junfeng Hui*, Monodisperse selenium-substituted hydroxyapatite: controllable synthesis and biocompatibility, Materials Science and Engineering C, 2017, 73: 596-602. (SCI二区, IF: 5.880)

[11]Pengjian Wang,Junfeng Hui, Tingbiao Yuan, Peng Chen, Yue Su, Wenjie Liang, Fulin Chen, Xiaoyan Zheng*, Yuxin Zhao* and Shi Hu*, Ultrafine nanoparticles of W-doped SnO2 fordurable H2S sensors with fast response andrecovery, RSC Advances, 2019, 9: 11046-11053. (SCI三区, IF:3.119)

[12]Pengjian Wang,Tingbiao Yuan, Huifang Yuan, Xiaoyan Zheng*, Hamza Ijaz,Junfeng Hui, Daidi Fan, Yuxin Zhao* and Shi Hu*,PdO/SnO2 heterostructure for low-temperaturedetection of CO with fast response and recovery, RSC Advances, 2019, 9, 22875-22882. (SCI三区, IF:3.119)

[13]Gaoyu Chen#,Xiaoyan Zheng#,ChongWang,Junfeng Hui,Xuexi Sheng,Xiangxing Xu*,Jianchun Bao,Weijun Xiu,Lihui Yuwen*andDaidi Fan*, A postsynthetic ion exchange method for tunable doping of hydroxyapatite nanocrystals, RSC Advances, 2017,7: 56537-56542.(SCI三区, IF: 3.119)

[14]Chunning Heng#, Xiaoyan Zheng#, Meiying Liu, Dazhuang Xu, Hongye Huang,FengjieDeng, Junfeng Hui*, Xiaoyong Zhang*, Yen Wei*, Fabrication of luminescent hydroxyapatite nanorods throughsurface-initiatedRAFT polymerization: Characterization, biologicalimagingand drug delivery applications, Applied Surface Science, 2016, 386: 269–275.(SCI二区, IF:6.182 )

[15]Ningxia Xu, Jing Xu, Xiaoyan Zheng, and Junfeng Hui*, Preparation of Injectable Composite Hydrogels by BlendingPoloxamers with Calcium Carbonate-Crosslinked SodiumAlginateChemistryOpen, 2020, 9: 451-458.(SCI三区, IF:2.370 )

[16]CongyuKe, Guomin Lu, Yinglin Wei, Wujuan Sun, Junfeng Hui, Xiaoyan Zheng,Qunzheng Zhang, Xunli Zhang*,Biodegradation of crude oil by Chelatococcusdaeguensis HB-4 and itspotential for microbial enhanced oil recovery (MEOR) in heavy oil reservoirs, Bioresource Technology, 2019, 287: 121442.(SCI一区, IF:7.539)

[17]Chunning Heng,Xin Zhou,Xiaoyan Zheng,Meiying Liu,Yuanqing Wen,Hongye HuangDaidi Fan,Junfeng Hui*,Xiaoyong Zhang*,Yen Wei*. Surface grafting of rare-earth ions doped hydroxyapatite nanorods (HAp:Ln(Eu/Tb)) with hydrophilic copolymers based on ligand exchange reaction: Biological imaging and cancer treatment, Materials Science & Engineering C, 2018, 556-563.(SCI二区, IF: 5.880)

[18]CongyuKe, Wujuan Sun*, Yongbin Li, Junfeng Hui, Guomin Lu, Xiaoyan Zheng, Qunzheng Zhang, Xunli Zhang*. Polymer-Assisted Microbial-Enhanced Oil Recovery. Energy & Fuels, 2018, 32: 5885-5892.(SCI二区, IF: 3.421)

[19]Chunning Heng, Meiying Liu, Pengfei Wang, Ke Wang, Xiaoyan Zheng, Daidi Fan, Junfeng Hui*, Xiaoyong Zhang*, Yen Wei*. Preparation of Silica Nanoparticles based Multifuctional Therapeutic Systems via One-step Mussel Inspired Modification,Chemical Engineering Journal, 2016, 296: 268-276. (SCI一区, IF: 10.652 )

[20]Chunning Heng, Meiying Liu, Ke Wang, Xiaoyan Zheng, Hongye Huang, Fengjie Deng, Junfeng Hui*, Xiaoyong Zhang*, Yen Wei*. Fabrication of silica nanoparticle based polymer nanocomposites via a combination of mussel inspired chemistry and SET-LRP, RSC Advances2015, 5, 91308–91314.(SCI三区, IF=3.119)